Salay range: 31115 to 39004pa plus excellent benefits. Fixed-term for 3 years
In the Parasite genomics group, we use large-scale sequencing approaches to study parasitic diseases of global importance, with a particular emphasis on neglected tropical diseases (NTDs). We are particularly focusing on the biology of schistosomes, one of the most important and neglected parasites, which infects 250 million of the world's poorest people.
We are seeking an enthusiastic and ambitious postdoctoral fellow to work on the evolutionary genomics of Schistosoma and related schistosomatids. You will take advantage of recent advances in rapidly producing high-quality assemblies and utilize our recently completed high-quality assemblies of schistosome autosomes and sex chromosomes. Using large-scale comparative genomics of schistosomes, you will identify genomic features shared across different evolutionary scales and find lineage-specific differences associated with different host tropisms and other traits.
Our lab generates extensive functional genomic data for S. mansoni and you will be able to take advantage of the Institute's world-leading expertise and resources for genome sequencing and mapping. The ongoing functional genomics work in the group means that it will be possible to collaborate with other members of the team to test hypotheses arising from in silico work.
The exact project will depend on the skills and interests of successful applicant, but could include:
Identify conserved non-coding elements and investigate their evolution across divergent schistosomatids.
Investigate the genomic basis of convergent host tropism between two different mammalian-infective lineages (Schistosomatium and Schistosoma) that are independently derived from avian-infective ancestors
Reconstruct the evolution of schistosome sex chromosomes and understand the movement of genes between sex chromosomes and autosomes. (Schistosome are unusual amongst parasitic flatworms, in having evolved dioecy and a ZW sex determination system.)
to develop, drive and deliver cutting edge research on the genome biology of schistosomes
assembly and annotation of genomic sequence data, leading to the preparation of manuscripts for publication
development and validation of novel analytical methods where required
effective communication with collaborators and colleagues and through presentation at international meetings
design of spin-off research projects and follow-up studies
Strong track record of academic achievement, including a PhD or equivalent in a relevant biological subject
Experience and strong technical skills in genomics or bioinformatics and ideally in some combination of these disciplines
Strong working knowledge of statistical analysis
Experience of working on schistosomes
Detailed understanding of molecular biology
Experience collaborating with field researchers, epidemiologists or clinicians
Experience in combining computational and laboratory work
Experience of working with next-generation sequencing data
Experience working in a Unix computing environment
Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.
Closing date for applications: 7th September 2017.Please include a covering letter and CV with your application.
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Apply above for Postdoctoral Fellow in Schistosome Genomics jobs in Cambridgeshire.